Figure 5
From: FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system
Structure and interaction of the Skp1-FBXW7-DISC1 PD complex. (a) Dissociation constants determined by ITC for different DISC1 PD peptides. (b) Overall architecture of the complex. Skp1, FBXW7, and DISC1 are in blue, green, and orange, respectively. (c) Binding of the DISC1 peptide at the top face of the WD40 domain of FBXW7. The eight FBXW7 blades and the strands for one blade are labeled. (d) Close-up view of the DISC1-FBXW7 interface showing interacting amino acids of FBXW7 (light green) and DISC1 (orange).
