Table 1 Summary of results

From: The thalamic reticular nucleus in schizophrenia and bipolar disorder: role of parvalbumin-expressing neuron networks and oxidative stress

Diagnosis

Total number of PV neurons

Total number of PNNs

TRN volumes

 

Percent diff.

g value

Percent diff.

g value

Percent diff.

g value

SZ

⇓−71.1%a

⇓−2.08%a

⇓−81.3%a

⇓−1.40%a

⇓−18.1%

⇓−0.75

BD

⇓−72.1%b

⇓−1.88%b

⇓−57.1%

⇓−0.77%

⇓−21.7%

⇓−0.83

  1. Abbreviations: ANCOVA, analysis of co-variance; BD, bipolar disorder; PNN, perineuronal net; PV, parvalbumin; SZ, schizophrenia; TRN, thalamic reticular nucleus; WFA, Wisteria Floribunda agglutinin.
  2. Percent differences for Tn and volume in disease groups with respect to the controls. Tn of PV neurons and WFA/PNNs were markedly decreased in the TRN of both SZ and BD groups, with large effect sizes. Modest volume decreases, measured on Nissl-stained sections, were not statistically significant. Bold values and arrows indicate statistically significant changes (ANCOVA analysis on log-transformed values). Percent changes are calculated on raw values, adjusted for the effects of the covariates with significant impact in the model; g-values are calculated on log transformed values, adjusted for the effects of the covariates with significant impact in the model.
  3. aadjusted for exposure to antipsychotics during last 6 months.
  4. badjusted for lifetime exposure to lithium.