Table 3 Genetic correlations between tiredness documented in the UK Biobank data set and the health-related variables collected from GWAS consortia

Trait category	Traits from GWAS consortia	r_g	s.e.	P
Physical health	Blood pressure: diastolic	0.0332	0.0502	0.5083
	Blood pressure: systolic	−0.0698	0.0478	0.1444
	BMI	0.2024	0.0322	3.18 × 10 ⁻¹⁰
	Cholesterol: HDL	−0.1087	0.0373	0.0036
	Cholesterol: LDL	0.0829	0.0413	0.0449
	Coronary artery disease	0.1338	0.067	0.0459
	C-reactive protein	0.0165	0.054	0.0021
	Grip strength^a	−0.1596	0.0482	0.0009
	HbA1c	0.2536	0.0857	0.0031
	Height	−0.0201	0.0297	0.4980
	Longevity	−0.3943	0.1096	0.0003
	Forced expiratory volume 1s^a	−0.1181	0.0538	0.0281
	Obesity	0.2063	0.0381	6.31 × 10 ⁻⁸
	Rheumatoid arthritis	−0.0181	0.0674	0.7885
	Self-rated health^a	−0.7780	0.0349	7.30 × 10 ⁻¹¹⁰
	Smoking status	0.2009	0.0603	0.0009
	Triglycerides	0.1324	0.0332	6.62 × 10 ⁻⁵
	Type 2 diabetes	0.1784	0.0689	0.0097
	Waist–hip ratio	0.2834	0.0417	1.09 × 10 ⁻¹¹
Mental health	ADHD	0.2694	0.1116	0.0158
	Alzheimer’s disease	0.0762	0.1079	0.4801
	Alzheimer’s disease (500 kb)	0.0613	0.0872	0.4816
	Anorexia nervosa	0.0192	0.0492	0.6967
	Autism	0.0129	0.0695	0.8522
	Bipolar disorder	0.1382	0.0605	0.0223
	Childhood cognitive ability	−0.1528	0.0891	0.0864
	Major depressive disorder	0.5902	0.1015	6.03 × 10 ⁻⁹
	Neuroticism	0.6150	0.038	7.34 × 10 ⁻⁵⁹
	Schizophrenia	0.2490	0.0386	1.14 × 10 ⁻¹⁰
	Verbal-numerical reasoning^a	−0.1379	0.0596	0.0206

Abbreviations: ADHD, attention deficit hyperactivity disorder; BMI, body mass index; FDR, false discovery rate; GWAS, genome-wide association study; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
Statistically significant P-values (after false discovery rate correction; threshold: P=0.0281) are shown in bold.
^aGWAS based on UK Biobank data.

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