Table 1 Summary of module characterization and phenotype association

From: EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction

Module

Module size

Genotype

Treatment

Interaction

Gene ontology enrichment

  
  

F

P

F

P

F

P

Category

N

P

Black

300

5.87

0.042

2.63

0.144

1.17

0.312

Response to organic substance (BP)

41

2.34E−04

Blue

566

1.56

0.246

7.46

0.026

0.93

0.362

Somitogenesis (BP)

9

9.41E−06

Brown

546

2.11

0.185

10.49

0.012

1.31

0.285

Negative regulation of JNK cascade (BP)

5

4.65E−04

Cyan

147

4.56

0.065

9.12

0.017

1.84

0.212

Oxidoreductase activity, acting on NAD(P)H, haem protein as acceptor (MF)

3

6.27E−05

Green

477

6.72

0.032

2.29

0.169

2.96

0.123

Multicellular organismal development (BP)

125

5.15E−11

Green yellow

172

14.46

0.005

1.11

0.323

0.00

0.981

Positive regulation of icosanoid secretion (BP)

3

4.64E−05

Light cyan

103

0.86

0.380

11.18

0.010

3.39

0.103

Extracellular region part (CC)

16

1.30E−05

Magenta

263

9.94

0.014

1.32

0.283

0.80

0.397

Tricarboxylic acid cycle (BP)

5

5.78E−05

Midnightblue

126

4.06

0.079

8.09

0.022

2.98

0.123

Negative regulation of cartilage development (BP)

2

1.75E−04

Pink

295

0.01

0.910

14.96

0.005

0.43

0.532

Positive regulation of interleukin-13 biosynthetic process (BP)

2

4.00E−04

Purple

192

0.36

0.564

13.09

0.007

0.54

0.485

Negative regulation of peptidyl-threonine phosphorylation (BP)

2

3.85E−03

Red

330

1.07

0.331

6.99

0.030

0.60

0.460

GTPase regulator activity (MF)

17

1.28E−03

Salmon

167

0.00

0.985

8.78

0.018

0.30

0.599

Rhythmic process (BP)

7

3.60E−04

Tan

170

1.71

0.227

23.07

0.001

5.87

0.042

Melanin biosynthetic process from tyrosine (BP)edede

2

1.19E−04

Turquoise

618

19.56

0.002

0.08

0.778

0.83

0.389

Extracellular region (CC)

84

7.47E−09

Yellow

537

0.15

0.705

11.98

0.009

0.02

0.885

Enzyme binding (MF)

67

6.56E−06

  1. Abbreviations: BP, biological process; CC, cellular compartment; MF, molecular function.
  2. CC, MF and BP are the three ontologies used to classify GO terms.