Table 3 Pathways enriched with ethanol-responsive genes from four co-expression modules
Pathway | N | FDR | Genes |
---|---|---|---|
Upregulated genes (yellow module) | |||
Lysine degradation | 8 | 2.25E−07 | Ehmt2, Setdb1, Plod1, Tmlhe, Whsc1l1, Gcdh, Ogdh, Plod2 |
Chemokine signalling pathway | 13 | 6.72E−07 | Pik3r5, Arrb2, Prkcd, Mapk3, Stat5b, Gnb1, Arrb1, Vav2, Ptk2b, Ptk2, Akt1, Stat3, Stat1 |
Natural killer-cell-mediated cytotoxicity | 9 | 3.18E−05 | Pik3r5, Mapk3, H2-D1, Itgb2, Lcp2, Fcer1g, Icam1, Vav2, Ptk2b |
PPAR signalling pathway | 7 | 7.99E−05 | Lpl, Rxra, Slc27a4, Acox1, Scd1, Slc27a1, Cpt1c |
Calcium signalling pathway | 10 | 1.05E−04 | Phkg1, Itpkb, Pde1b, Phka2, Mylk3, Grm1, Phkg2, Ptk2b, Camk2b, Adra1b |
Glycerophospholipid metabolism | 6 | 6.39E−04 | Chkb, Lpcat2, Agpat6, Pnpla6, Mboat7, Pla2g2d |
Inositol phosphate metabolism | 5 | 8.91E−04 | Inppl1, Inpp5a, Itpkb, Inpp5k, Isyna1 |
Jak–STAT signalling pathway | 8 | 9.49E−04 | Osmr, Pik3r5, Il7, Stat5b, Akt1, Il10rb, Stat3, Stat1 |
Long-term potentiation | 5 | 1.73E−03 | Mapk3, Rps6ka1, Grm1, Camk2b, Gria1 |
Phosphatidylinositol signalling system | 5 | 3.03E−03 | Inppl1, Pik3r5, Inpp5a, Itpkb, Inpp5k |
mRNA surveillance pathway | 5 | 5.18E−03 | Upf3b, Casc3, Smg6, Acin1, Upf1 |
Glutamatergic synapse | 6 | 5.66E−03 | Mapk3, Grm1, Gnb1, Pla2g2d, Dlg4, Gria1 |
Downregulated genes (tan, pink, and purple modules) | |||
MAPK signalling pathway | 17 | 8.26E−07 | Pdgfa, Fgf9, Map2k6, Gadd45b, Ptprr, Gadd45g, Nr4a1, Fgf5, Dusp1, Kras, Fos, Dusp5, Dusp6, Jun, Map3k14, Nras, Rras2 |
Tight junction | 10 | 3.97E−05 | Gnai1, Myl9, Ctnna2, Ppp2r2d, Myh2, Pard6b, Kras, Cask, Nras, Rras2 |
Osteoclast differentiation | 9 | 7.97E−05 | Nfkbia, Fosb, Map2k6, Fosl2, Junb, Fos, Jun, Map3k14, Socs3 |
Regulation of actin cytoskeleton | 11 | 4.80E−04 | Pdgfa, Fgf9, Myl9, Itga1, Itgae, Fgf5, Kras, Pip5k1b, Arpc3, Nras, Rras2 |
Cell cycle | 8 | 6.51E−04 | Gadd45b, Gadd45g, Ccne2, Cdkn2c, Cdk6, Ccnb2, Ccnh, Ccna1 |
B-cell receptor signalling pathway | 6 | 1.05E−03 | Nfkbia, Kras, Fos, Cd72, Jun, Nras |
Axon guidance | 7 | 4.06E−03 | Efna2, Gnai1, Rnd1, Kras, Cxcl12, Met, Nras |