Study suggests the Spanish Habsburgs evolved to mute the effects of inbreeding, but other geneticists are unconvinced.
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References
Ceballos, F. C. & Álvarez, G. Heredity http://dx.doi.org/10.1038/hdy.2013.25 (2013).
Alvarez, G., Ceballos, F. C. & Quinteiro, C. PLoS ONE 4, e5174 (2009).
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Callaway, E. Inbred royals show traces of natural selection. Nature (2013). https://doi.org/10.1038/nature.2013.12837
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DOI: https://doi.org/10.1038/nature.2013.12837