Sexually transmitted canine cancer has acquired almost 2 million mutations and is still going strong.
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References
Murchison, E. P. et al. Science 343, 437–440 (2014).
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Borrell, B. How a contagious dog tumour went global. Nature (2014). https://doi.org/10.1038/nature.2014.14580
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DOI: https://doi.org/10.1038/nature.2014.14580