Virus can quickly develop mutations that resist attack by DNA-shearing enzymes.
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References
Wang, Z. et al. Cell Rep. dx.doi.org/10.1016/j.celrep.2016.03.042 (2016); http://www.cell.com/cell-reports/abstract/S2211-1247%2816%2930298-4
Wang, G., Zhao, N., Berkhout, B. & Das, A. T. Mol. Ther. 24, 522–526 (2016).
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Callaway, E. HIV overcomes CRISPR gene-editing attack. Nature (2016). https://doi.org/10.1038/nature.2016.19712
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DOI: https://doi.org/10.1038/nature.2016.19712
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