Figure 3: The relationship between volatility and gene expression across the intraerythrocytic development cycle of P. falciparum.
From: Detecting selection using a single genome sequence of M. tuberculosis and P. falciparum
The lower panel shows the percentage of ring-stage (circles), trophozoite-stage (crosses) and schizont-stage (squares) parasites at each time point for which relative mRNA expression levels of 4,488 ORFs were measured4. The upper graph shows the Spearman correlation coefficient between gene expression level, Cy5/Cy3, and volatility P value among the genes of high (P < 0.001) and low (P > 0.999) volatility. Genes expressed during the ring stage are significantly correlated with high volatility, whereas trophozoite- and schizont-expressed genes generally exhibit low volatility. Of the 46 time points, 21 have significantly positive or negative correlations (P < 0.05 each).
