Figure 2: Diagrams of mutations found in the members of several receptor families in lung adenocarcinomas.
From: Somatic mutations affect key pathways in lung adenocarcinoma
a–e, Mutations in members of the EGF (a), EPH (b), FGF (c), NTRK (d) and VEGF (e) receptor families are shown. Protein domains are determined by using HMMPFAM. The PFAM domains include ‘L’ (receptor ligand binding domain), Fn3 (fibronectin type III domain), Ig (immunoglobulin domain), LRR (leucine rich repeat domain), LRRNT (leucine rich repeat amino-terminal domain), PTK (protein tyrosine kinase domain) and SAM (sterile α-motif). The locations of mutations are indicated by diamonds, circles and triangles, with filled shapes representing new mutations and open shapes denoting known mutations. The size of the shapes is positively proportional to the degree of conservation at the mutated residue. Representative scheme for each family is constructed based on the ClustalW2 alignment. Recurrent mutations are outlined in black.
