Figure 4: CHD7 rearrangements in SCLC cell lines.
From: A small-cell lung cancer genome with complex signatures of tobacco exposure
a, A somatically acquired 39.5-kb tandem duplication is found in NCI-H209. b, The LU-135 cell line shows co-amplification of the 3′ portion of CHD7 together with MYC and the 5′ portion of PVT1. Blue lines show locations of genomic rearrangements observed in the amplicons, with the thickness of the line proportional to the number of reads spanning the breakpoint. c, Transcripts resulting from CHD7 rearrangements are an in-frame duplication of exons 3–8 in NCI-H209 and two amplified PVT1–CHD7 fusion genes in NCI-H2171 and LU-135. d, CHD7 is overexpressed in SCLC compared to both non-small-cell lung cancer and other tumour types. LU-135 and NCI-H2171 show massive overexpression of CHD7 in keeping with the genomic amplification present in these cell lines.
