Figure 4: Bacterial species abundance differentiates IBD patients and healthy individuals.
From: A human gut microbial gene catalogue established by metagenomic sequencing
Principal component analysis with health status as instrumental variables, based on the abundance of 155 species with ≥1% genome coverage by the Illumina reads in at least 1 individual of the cohort, was carried out with 14 healthy individuals and 25 IBD patients (21 ulcerative colitis and 4 Crohn’s disease) from Spain (Supplementary Table 1). Two first components (PC1 and PC2) were plotted and represented 7.3% of whole inertia. Individuals (represented by points) were clustered and centre of gravity computed for each class; P-value of the link between health status and species abundance was assessed using a Monte-Carlo test (999 replicates).
