Figure 1: Evidence for transcription-coupled repair and functional importance of statistically significant mutations.
From: Initial genome sequencing and analysis of multiple myeloma
a, Intronic mutation rates subdivided by gene expression rates in multiple myeloma. Rates of gene expression were estimated by proportion of Affymetrix Present (P) calls in 304 primary multiple myeloma samples. Error bars indicate ±1 standard deviation. NS, not significant. b, Functional importance (FI) scores were generated for all point mutations and divided into distributions for nonsignificant mutations (top histogram; n = 1,019) and significant mutations (bottom; n = 36). Comparison of distributions is via the Kolmogorov–Smirnov statistic.
