Figure 2: Mutations likely to affect protein translation and/or homeostasis in multiple myeloma.
From: Initial genome sequencing and analysis of multiple myeloma
a, Alignment of human, yeast and bacterial RNB domain of DIS3. Positions of observed mutations are indicated with respect to the human sequence. Yeast equivalents are, respectively, S541, V568, G833 and R847. b, One-dimensional and three-dimensional structures of yeast DIS3, with the RNB domain coloured in blue and mutations coloured in red. c, GSEA plot showing enrichment of ribosomal protein gene set among genes correlated with FAM46C expression in 414 multiple myeloma samples.
