Table 1 Statistically significant protein-coding mutations in multiple myeloma
From: Initial genome sequencing and analysis of multiple myeloma
Gene | N | n | Untreated n | CpG transition | Other C:G transition | C:G transversion | A:T mutation | Indel/ null | P-value | q-value |
|---|---|---|---|---|---|---|---|---|---|---|
NRAS | 20,711 | 9 | 3 | 0 | 0 | 3 | 6 | 0 | <1.0 × 10−11 | <1.0 × 10−6 |
KRAS | 25,728 | 10 | 6 | 0 | 5 | 1 | 4 | 0 | <1.0 × 10−11 | <1.0 × 10−6 |
FAM46C | 39,661 | 5 | 3 | 0 | 0 | 2 | 1 | 2 | 1.8 × 10−10 | 1.0 × 10−6 |
DIS3 | 89,758 | 4 | 1 | 0 | 1 | 1 | 2 | 0 | 2.4 × 10−6 | 0.011 |
TP53 | 32,585 | 3 | 1 | 0 | 0 | 1 | 1 | 1 | 5.1 × 10−6 | 0.019 |
CCND1 | 12,899 | 2 | 1 | 0 | 0 | 0 | 2 | 0 | 0.000027 | 0.086 |
PNRC1 | 19,621 | 2 | 2 | 0 | 1 | 0 | 0 | 1 | 0.000039 | 0.094 |
ALOX12B | 40,369 | 3 | 0 | 1 | 0 | 1 | 1 | 0 | 0.000042 | 0.094 |
HLA-A | 18,635 | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 0.000045 | 0.094 |
MAGED1 | 53,950 | 2 | 1 | 0 | 0 | 0 | 0 | 2 | 0.000053 | 0.10 |
