Figure 1: Sensor, well and chip architecture.
From: An integrated semiconductor device enabling non-optical genome sequencing
a, A simplified drawing of a well, a bead containing DNA template, and the underlying sensor and electronics. Protons (H+) are released when nucleotides (dNTP) are incorporated on the growing DNA strands, changing the pH of the well (ΔpH). This induces a change in surface potential of the metal-oxide-sensing layer, and a change in potential (ΔV) of the source terminal of the underlying field-effect transistor. b, Electron micrograph showing alignment of the wells over the ISFET metal sensor plate and the underlying electronic layers. c, Sensors are arranged in a two-dimensional array. A row select register enables one row of sensors at a time, causing each sensor to drive its source voltage onto a column. A column select register selects one of the columns for output to external electronics.
