Table 1 MITF E318K association with melanoma

From: A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

Population

Group

No. of individuals with variant

No. of individuals without variant

Variant carrier frequency

OR

95% CI

One-sided exact P

Two-sided exact P

Australia

Cases

34

2,025

0.0165

2.33

1.21–4.70

0.0045

0.0083

 

Controls

14

1,939

0.0072

    

UK

Cases

34

1,895

0.0176

2.09

1.14–3.94

0.0074

0.0115

 

Controls

18

2,097

0.0085

    

Australia + UK

Cases

68

3,920

0.0171

2.19

1.41–3.45

0.0001

0.0003

 

Controls

32

4,036

0.0079

    
  1. It should be noted that the reported allele frequencies for MITF E318K in the population-based samples are without removing individuals with CDKN2A or CDK4 mutations, as screening for these genes was not routinely performed.
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