Figure 3: Looping landscape of TSSs to distal fragments.
From: The long-range interaction landscape of gene promoters
a, Composite profile of average number of group-specific looping interactions upstream and downstream of TSSs on the basis of combined 5C interaction data from the three cell lines. The top panel shows the average looping profiles of all TSSs (left), of expressed TSSs (middle) and of non-expressed TSSs (right). The bottom set of plots shows the corresponding profiles of all interrogated TSS–distal element interactions (left), of expressed TSSs (middle) and of non-expressed TSSs (right). All the interaction data for a particular group for all three cell lines are binned with a sliding window of 150 kb (step size of 5 kb) and normalized for the number of TSSs. b, Histogram showing the number of distal fragments that are involved in looping with their target promoters skipping 0,1,2,…,25 (and above) TSSs. c, Histogram showing the number of looping interactions that skip over 0, 1, 2,…, 25 (and above) restriction fragments bound by either CTCF (left) or by both CTCF and RAD21 (cohesin; right). In b and c combined results for all three cell lines are plotted and values above 24 on the x axis are added and grouped as 25+. Percentage of looping interactions that skip ≥1 CTCF (left) or CTCF plus cohesin (right) are indicated on top.
