Figure 5: Driver initiation and progression mutations and tumour clonal architecture.
From: Mutational landscape and significance across 12 major cancer types
a, Variant allele fraction (VAF) distribution of mutations in SMGs across tumours from AML, BRCA and UCEC for mutations (≥20× coverage) in copy neutral segments. SMGs having ≥5 mutation data points were included. ChrX, chromosome X. b, In AML sample TCGA-AB-2968 (WGS), two DNMT3A mutations are in the founding clone, and one NRAS mutation is in the subclone. In BRCA tumour TCGA-BH-A18P (exome), one FOXA1 mutation is in the founding clone, and PIK3R1 and MLL3 mutations are in the subclone. In UCEC tumour TCGA-B5-A0JV (exome), PIK3CA, ARID1A and CTCF mutations are in the founding clone, and NRAS, PTEN and KRAS mutations are in the secondary clone. Asterisk denotes stop codon.
