Extended Data Figure 6: Systemic polymicrobial infection in Muc5b^−/− mice.

a–e, Bacteria from spleen homogenates obtained from moribund Muc5b^−/− mice and Muc5b^+/+ controls were identified by 16SrRNA gene sequencing. a, Genera in spleens from Muc5b^−/− mice (red circles). Staphylococcus was identified in the spleen of a single Muc5b^+/+ control (blue circle), but its incidence was 20% compared to 80% in Muc5b^−/− mice (b). c, Sequence identification of staphylococci present. d, e, Prevalence and abundance of streptococci. Data were analysed by ANOVA in a, c, e, and using chi-squared tests in b, d. P < 0.05 was considered significant. Total numbers of mice in each group are listed as denominators below b and d.