Extended Data Figure 10: Details of domain interactions and outer pore configurations.
From: Structure of the TRPV1 ion channel determined by electron cryo-microscopy
a–d, Cryo-EM densities (grey mesh) of highlighted regions of TRPV1, as indicated, at 3.4 Å resolution are superimposed onto atomic model. Map was low-pass filtered to 3.4 Å and amplified by a temperature factor −100 Å2. e, Superimposition of TRPV1 (salmon) with KV 1.2–2.1 chimaera (PDB 2R9R; grey). f, Superimposition of TRPV1 (salmon) with NaVAb (PDB 3RVY; blue). In each case, substantial structural differences are observed in the outer pore region. Structural alignments are based on the pore domain (S5–P–S6).
