Extended Data Figure 2: Sequence alignment of TRPV1 to other TRPV family members.
From: Structure of the TRPV1 ion channel determined by electron cryo-microscopy
The rat TRPV1 construct used for this study consists of residues 110 to 764 (indicated by red arrows), excluding the highly divergent region (604–626, highlighted by cyan box). Secondary structure elements are indicated above the sequence. The starting points of six ankyrin repeats are based on a crystal structure of ARD of TRPV1 (PDB 2PNN). Several critical residues discussed in the text are labelled in blue, and conserved glycine and proline residues at the turn of a β-sheet (highlighted in Fig. 6) are indicated with red stars.
