Extended Data Figure 4: 3D reconstruction of TRPV1–capsaicin complex low-pass filtered at 6 Å resolution.
From: TRPV1 structures in distinct conformations reveal activation mechanisms
a–d, Four different views of the 3D reconstruction low-pass filtered at 6 Å and amplified by a temperature factor of −100 Å2, fitted with de novo atomic model of TRPV1–capsaicin complex built as described in Methods. e, f, Two views of the 3D reconstruction displayed at two different isosurface levels (high in yellow and low in grey). At the low isosurface level, the belt-shaped density of amphipols is visible with a thickness of ∼30 Å.
