Extended Data Figure 9: S1–S4 as a stationary domain.
From: TRPV1 structures in distinct conformations reveal activation mechanisms
a, Superimposition of apo and RTX/DkTx-bound TRPV1 structures (orange and blue, respectively) from top-down view. S1–S4 domain (outlined in dashed box) shows near-complete overlap. b, Same comparison for apo and capsaicin-bound channel structures (orange and green, respectively). c, d, Superimposition of transmembrane core of apo versus RTX/DkTx- or capsaicin-bound TRPV1 structures (orange, blue and green, respectively). Dashed box denotes region highlighted in Fig. 6.
