Extended Data Figure 1: Cryo-EM of TRPV1 in complex with RTX and DkTx.
From: TRPV1 structures in distinct conformations reveal activation mechanisms
a, b, Fourier transform (a) of a representative image (b). c, Two dimensional (2D) class averages of cryo-EM particles. d, Enlarged view of three representative 2D class averages. Arrows indicate DkTx densities near the channel pore. e, Gold-standard FSC curve (red) of the final 3D reconstruction, marked with the resolutions that correspond to FSC = 0.5 and 0.143. The FSC curve between the final map and that calculated from the atomic model is shown in blue. f, Euler angle distribution of all particles used for calculating the final 3D reconstruction. The sizes of balls represent the number of particles. The accuracy of rotation is 5.213°, as reported by RELION.
