Extended Data Figure 6: Specific deletion of the miR-142-3p binding sites in the 3′ NTR of wild-type EEEV does not alter replication in BHK-21 fibroblasts.
From: RNA viruses can hijack vertebrate microRNAs to suppress innate immunity
a, EEEV 142del virus contains four deletions corresponding to the complimentary nucleotides in the 3′ NTR that bind to miR-142-3p, eliminating all four miR-142-3p binding sites. b, EEEV 142pm virus contains three point mutations in each of the miR-142-3p binding sites that correspond to the seed sequence of miR-142-3p. c, Replication of wild-type EEEV and 11337 in BHK-21 cells. n = three independent experiments. Error bars indicate geometric mean ± s.d.
