Extended Data Figure 7: Cumulative clone size distributions derived from two border mother cells. | Nature

Extended Data Figure 7: Cumulative clone size distributions derived from two border mother cells.

From: Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging

Extended Data Figure 7

Cumulative clone size distributions of clones derived from two neighbouring cells in the border region. In each case, the size of the clone is defined by the total number of constituent cells in the central and border regions (rows 0 to +4), independent of GFP expression. Note that the cumulative clone size distribution records the fraction of clones that have a size larger than the given value. The bars represent measurements from individual lineages reconstructed from live imaging at days 1 (a, n = 13; b, n = 35; c, n = 35), 2 (a, n = 10; b, n = 25; c, n = 28), 3 (a, n = 7; b, n = 14; c, n = 14) and 4 (a, n = 6; b, n = 8; c, n = 6). Error bars denote s.e.m. The points represent the predictions of the biophysical model using the same parameters as those inferred from the short-term live-imaging assay (for details, see Fig. 3a and Supplementary Notes).

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