Extended Data Figure 5: Average clone size and survival probability.

Cartoon shows the division of the intestinal stem-cell niche into a central and border region. The central region contains rows 0 to +2, which translates to z0 to z6 of the z-stack, and the border region contains rows +3 and +4, which translates to z7 to z13 of the z-stack (see Fig. 1b). Confetti expression was induced in Lgr5⁺ CBC cells. The panels show, at the indicated time, the spatial organization of the 80 lineages of progeny of the Confetti-labelled CBC cells (same clones as in Extended Data Figs 2, 4) (n = 4 mice). For each lineage, we recorded the number of cells per clone in the central and border regions of the stem-cell niche at the indicated times. The first time point translates to several days after induction. The asterisks indicate clones in which all progeny were lost from the niche region.