Extended Data Figure 9: Correlation of XBP1 with HIF1α in patients with TNBC.
From: XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
a, b, Expression of XBP1 signature is highly correlated with two publicly available hypoxia-driven signatures in TNBC patients (a), but not in ER+ breast cancer patients (b). The scatter plots of XBP1 and two publicly available HIF1α signatures (left panel, HIF1α pathway; right panel, hypoxia via HIF1α pathway) across different tumours were drawn for TNBC (a) and ER+ breast cancer patients (b), respectively. The corresponding Pearson’s correlation coefficient (r) between XBP1 and HIF1α signature is shown. c, d, Kaplan–Meier graphs demonstrating no significant association of the expression of the XBP1 signature (red line) (c) or HIF signature (d) with relapse-free survival in oestrogen-receptor-positive breast cancer patients. The log-rank test P values are shown.
