Extended Data Figure 4: Structural metrics for the computational design models.

Selected metrics related to the designed interfaces are plotted for the 57 designs that were experimentally characterized, including a, the predicted binding energy measured in Rosetta energy units (REU), b, the surface area buried by each instance of the designed interface, c, the binding energy density (calculated as the predicted binding energy divided by the buried surface area), d, the number of buried unsatisfied polar groups at the designed interface, e, the shape complementarity of the designed interface, and f, the total number of mutations in each designed pair of proteins. Each circle represents a single design; the five successful materials are plotted as filled circles and labelled. In each plot, the designs are arranged on the x axis in order of increasing value of the metric analysed.