Figure 2: Molecular characteristics of EBV-positive gastric cancers.
From: Comprehensive molecular characterization of gastric adenocarcinoma
a, The heatmap represents unsupervised clustering of DNA methylation at CpG sites for 295 tumours into four clusters: EBV-CIMP (n = 28), Gastric-CIMP (n = 77), cluster 3 (n = 73) and cluster 4 (n = 117). Profiles for non-malignant gastric mucosa are to the left of the tumours. b, The proportion of tumours harbouring PIK3CA mutation in the molecular subtypes with mutations at sites noted recurrently in this data set or in the COSMIC database marked separately (top). Locations of PIK3CA mutations with the subtype of the sample with each mutation colour-coded (bottom).
