Extended Data Figure 7: RNA exosome substrate antisense transcripts are expressed within gene bodies and regulatory regions containing AID-induced translocations.
From: Noncoding RNA transcription targets AID to divergently transcribed loci in B cells
a, Association of genes with TSS-RNA expression, antisense transcripts and AID-induced translocations. The xTSS-RNA and antisense transcripts groups were compiled from four and two biological replicates, respectively. b, Examples of genes with asRNA transcription (Exosc3WT/WT in blue and Exosc3COIN/COIN in red) at regions that have been shown to have translocations from the Igh locus (translocations indicated in black). Data were compiled from two biological replicates. c, Translocations present in the upstream regulatory regions of AID target gene Cd83 (top panel) occur over regions of RNA exosome-sensitive antisense transcription. Data were compiled from two biological replicates.
