Extended Data Figure 8: Genome-wide analysis of xTSS-RNA expression at genes with AID, Spt5 and RPA occupancy.
From: Noncoding RNA transcription targets AID to divergently transcribed loci in B cells
a, Scatter plot of antisense (left) and sense RNA transcription (right) in Exosc3WT/WT and Exosc3COIN/COIN transcriptomes. Data were compiled from two biological replicates. b, Genome-wide analysis of xTSS-RNA expression at genes that are expressed and possess or lack AID and/or Spt5 occupancy. Values beneath each group represent the number of genes with indicated occupancy. P values were determined by Wilcoxon rank-sum test. c, Overlap of genes with xTSS-RNA transcription (pink), recurrent AID-dependent chromosomal translocations (green) and RPA occupancy in the mouse B-cell genome (brown). The xTSS-RNA group was compiled from four biological replicates. **P < 0.01 (Fisher’s exact test).
