Extended Data Figure 1: Enhanced FcRn-binding mutants of VRC01 are released from human FcRn at pH 7.4.
From: Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
VRC01 or the indicated FcRn-binding mutants were injected in PBS (pH 6.0) at a concentration of 100 nM over human-FcRn-immobilized Biacore CM5 sensor chips (∼500 response units (RU)) and were dissociated using PBS at pH 6.0 followed by PBS at pH 7.4.
