Extended Data Figure 4: δ-cells dedifferentiate, proliferate and reprogram into insulin production after extreme β-cell loss in juvenile mice.
From: Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers
Observed and expected numbers of Sst+ and insulin+ cells per islet section, before and after β-cell ablation. Cells scored after 6 weeks (Extended Data Fig. 3a) correspond (χ2 test) with estimates made assuming that dedifferentiated proliferating δ-cells yield two types of progeny (as deduced from Fig. 2c, e). Dashed arrows indicate phenotypic stability; plain arrows indicate dynamic behaviour (dedifferentiation and replication).
