Extended Data Figure 5: Co-housing does not alter disease progression in LFD-fed Pstpip2cmo mice.
From: Dietary modulation of the microbiome affects autoinflammatory disease

a, Pstpip2cmo mice were treated with a cocktail of broad-spectrum antibiotics in their drinking water. Faecal samples were collected from wild-type (n = 5) and Pstpip2cmo mice that received either regular drinking water (n = 5) or antibiotics water (n = 11) 5–7 weeks later. Prevotella and Flexispira 16S rDNA copy numbers were quantified and normalized to total bacteria. The bar graphs depict the mean ± s.e.m. b, Faecal microbiota from diseased Pstpip2cmo mice was orally transplanted into wild-type mice (Pstpip2cmo microbiota ≫ wild type) and the incidence of inflammatory bone disease in control Pstpip2cmo and faecal transplantation mice was evaluated. c, d, Pstpip2cmo mice were singly housed or co-housed with wild-type (c) or Il1b-deficient Pstpip2cmo (d) mice. Clinical development of bone deformity and arthritic inflammation in hind paws and tails was monitored over time. **P < 0.01, ***P < 0.001; Student’s t-test.