Extended Data Figure 7: Inflammatory markers in epididymal white adipose tissue from ob/ob mice treated with MEK inhibitors.
From: An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
Gene expression analysis was performed on M1 macrophage markers Nos2 and tumour necrosis factor-α (TNF-α); M2 macrophage markers Arg1, Chil3, Il10, Itgax, Clec10a/Mgl1 and Mgl2; chemotactic ligand Ccl2 and receptor Ccr2; and macrophage surface markers Emr1, Cd68 and Csf1r (n = 7 or 8 mice per group as in Fig. 5f, h). Gene expression was analysed by ANOVA. Error bars indicate s.e.m. *P < 0.05; **P < 0.01; ***P < 0.001.
