Extended Data Figure 4: Conservation of the sites on MEK2 phosphorylated by Cdk5. | Nature

Extended Data Figure 4: Conservation of the sites on MEK2 phosphorylated by Cdk5.

From: An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

Extended Data Figure 4

Mouse MEK2 T395/T397 corresponds to human MEK2 T394/T396. These sites share identity with MEK1 T386/T388 in both humans and mouse. Cdk5 has previously been shown to phosphorylate MEK1 at T286, a site not shared with MEK2. ERK has been shown to phosphorylate MEK1 T386 and contribute to regulation of kinase activity31. Homo, Homo sapiens; trog, Pan troglodytes; mus, Mus musculus; rat, Rattus norvegicus; bos, Bos taurus; canis, Canis lupus familiaris.

Back to article page