Extended Data Figure 4: Sequence alignment of DNMT3 family members.
From: Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
Sequences of human DNMT3A (NP_072046), DNMT3B (NP_008823), DNMT3L (NP_787063), mouse Dnmt3a (NP_031898), zebrafish Dnmt3a (NP_001018150), and DNA methyltransferase from Haemophilus parahaemolyticus (WP_005706946) used in the alignment. Highly conserved and identical residues are highlighted with dark green background, and conserved residues are indicated with light green background. Secondary structural elements are coloured as in Fig. 1a and indicated above the sequences. Invisible residues in the structure of ADD–CD–CDNMT3L are indicated as dashed lines above the sequences. Residues involved in ADD–CD interactions in active form or autoinhibitory form are indicated as black stars and red triangles, respectively. Residues involved in H3–ADD interactions are indicated as blue squares.
