Extended Data Table 2 Effect of DNMT3A mutants on autoinhibition

From: Structural insight into autoinhibition and histone H3-induced activation of DNMT3A

  1. All mutants were made on ADD–CD (residues 476–912) and the protein complexes ADD–CD–CDNMT3L were used for the assays. ‘Release’ represents release of the autoinhibition by at least twofold activity enhancement. ‘Inhibition’ represents inhibition of activity and no response to H3 peptides. ‘No-change’ indicates that the mutants behaved similar to wild-type protein. ‘Decrease’ represents decrease or loss of enzymatic activity.
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