Extended Data Figure 6: Model of the PCP7–X–OxyBtei complex in two possible arrangements.
From: X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis
a–d, Possible PCP position determined from the alignment of the P450sky–PCP7 complex trapped using a covalent azole inhibitor with the OxyBtei–X-domain complex (a, b) and the structure of the P450BioI–ACP complex (c, d). The X-domain is shown in grey, OxyBtei is shown in yellow, the haem of OxyBtei is shown in red sticks. a, b, The PCP7 (sky) is shown in magenta and the azole inhibitor covalently bound to the PCP is shown as pink sticks. c, d, The ACP is shown in blue and the phosphopantetheine-bound fatty acid is shown as blue sticks. The distance between the C terminus of the PCP/ACP and the N terminus of the X-domain is shown in a and c.
