Extended Data Figure 4: X-domain active site in comparison to TycC5–6.
From: X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis
a, b, Comparisons of the X-domain both in isolation (green/orange; a) and in complex with OxyBtei (green/orange; b) to the active site of TycC5–6 (grey, solved with a bound sulphate ion): the effect of the altered X-domain active-site motif is to block the active site. Selected residues are shown as sticks. Hydrogen bonds are indicated by dashed black/grey lines for the X-domain and in red for the TycC5–6/sulphate distance.
