Extended Data Figure 9: Graphical summary.
From: Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
Left, tumour without active β-catenin signalling in which ATF3 transcription is not induced and thus CCL4 (red circles) is transcribed and secreted. Downstream CD103+ dendritic cells (DC) (blue) are attracted and subsequent activation of CD8+ T cells (green) is enabled. Right, tumour with active β-catenin signalling (green), which leads to induction of ATF3 transcription (red), which in turn leads, among others effects, to suppression of CCL4 transcription. This leads to an active escape from the anti-tumour immune response since dendritic cell recruitment is insufficient.
