Extended Data Figure 10: Expression profiling of K8- and Lgr5-CreERT2/PIK3CAH1047R mammary tumours. | Nature

Extended Data Figure 10: Expression profiling of K8- and Lgr5-CreERT2/PIK3CAH1047R mammary tumours.

From: PIK3CAH1047R induces multipotency and multi-lineage mammary tumours

Extended Data Figure 10

a, Principle component analysis and dendogram of a hierarchical clustering of gene expression profiles from 10 K8- and 10 Lgr5-CreERT2/PIK3CAH1047R tumours and 2–3 reference mammary glands. Each dot indicates one sample. Circles represent K8-CreERT2 and squares represent Lgr5-CreERT2 animals expressing PIK3CAH1047R (filled symbols) or not (open symbols). b, Heat map of the top 1,000 genes that vary between K8-CreERT2/PIK3CAH1047R and Lgr5-CreERT2/PIK3CAH1047R tumours and The Cancer Genome Atlas (TCGA) human breast cancer gene signatures. Lum, luminal.

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