Extended Data Figure 1: Scheme depicting mouse lines generated for lineage-tracing studies.
From: PIK3CAH1047R induces multipotency and multi-lineage mammary tumours
a, Lgr5-CreERT2(ref. 25) or K8-CreERT2(ref. 1) animals were crossed to transgenic lox-STOP-lox PIK3CAH1047R 16 and/or Tomato-reporter mice, generating Lgr5-CreERT2/Tomato, K8-CreERT2/Tomato, Lgr5-CreERT2/PIK3CAH1047R/Tomato and K8-CreERT2/PIK3CAH1047R/Tomato animals for lineage-tracing studies. Lgr5-CreERT2/Tomato and K8-CreERT2/Tomato animals were used as controls. b, Lgr5-CreERT2(ref. 25) and K8-CreERT2(ref. 1) animals were crossed to lox-STOP-lox PIK3CAH1047R(ref. 16) or PIK3CAWT(ref. 18) animals. Lgr5-CreERT2 and K8-CreERT2 animals were used as controls. Tamoxifen injection induces PIK3CAH1047R, PIK3CAWT and/or Tomato expression.
