Extended Data Figure 1: Homozygosity for a Gsdmd point mutation correlates with unresponsiveness to cytoplasmic LPS.
From: Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Gsdmd genotypes and screen phenotypes of mice derived from IGL1351 pedigree (top). Only the identification numbers of screened animals are shown. Thirty-nine SNV genotypes mutated in the pedigree and their phenotypes (bottom). Hits represent mice whose peritoneal macrophages showed attenuated LPS-induced IL-1β secretion to a similar extent as Casp11 mutant 129 strain. Mutant, homozygous.
