Extended Data Figure 9: LMX1A, EOMES, and LHX2 are master transcriptional regulators of Group 4 medulloblastoma.

This figure accompanies Fig. 5. a, Subgroup-specific regulatory circuitry. Nodes are TFs associated with an SE in a subgroup-specific context. Edges indicate co-regulating TFs as defined by enrichment of TF binding motifs in respective regulatory regions. Edges validated by TF ChIP-seq are coloured according to their respective subgroup association. b, Network involving LHX2, LMX1A, and EOMES TFs and target genes inferred based on the presence of the respective TF motifs in Group 4-specific enhancers. Target genes are coloured according to their validation status based on LMX1A and LHX2 ChIP-seq, with genes arranged in the centre of the network inferred to be targeted by all three master TFs. For visualization purposes, these common targets are displayed with a larger font size compared to the genes in the surrounding network.