Extended Data Figure 3: Strongest continuous diffraction occurs with strongest Bragg diffraction.

a, Two-dimensional histogram of patterns, sorted by the integrated counts in the continuous component of the diffraction pattern (in a q range of 0.22–0.34 Å⁻¹) and the integrated signal in all detected Bragg peaks, for all 25,585 indexed patterns. We chose the 2,848 patterns with the strongest continuous diffraction signal above 17 X-ray counts (purple line) in the q region to generate the 3D continuous pattern shown in Fig. 2c. The featureless background due to scattering from the solvent contributes 10 X-ray counts (blue line). b, The measurement from the liquid jet without crystals. c, d, Two representative patterns with speckle counts above the mean solvent background, but not above the threshold (c), and one of the 2,848 strongest patterns (d), as indicated by the positions of the yellow circles in a.