Extended Data Figure 5: Further characterization of IgA responses to members of the microbiota in the USA twin cohort.
From: Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice
a. Evidence that IgA indices are independent of relative abundance. IgA indices for all OTUs are plotted against their relative abundance in the ‘input fraction’ for all infant/child, maternal, and gnotobiotic mouse faecal samples analysed by BugFACS (n = 22,713 comparisons). b, Mean IgA indices ± s.e.m. for two OTUs whose IgA targeting varied significantly with age across all 80 individuals in the twin birth cohort (FDR-corrected Kruskal–Wallis test, P < 0.05). c, Variance of IgA indices as a function of age. A total of 26 OTUs were detected in at least two individuals in all of the age bins surveyed. The variance in their IgA indices was then calculated and the non-parametric repeated-measures Friedman test was used to test for statistical significance (P < 0.0001). Mean values + s.e.m. are plotted.
