Extended Data Figure 3: Synthesis of the mTOR bivalent inhibitor RapaLink-1.
From: Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
a, Compound design of RapaLink-1, -2, and -3 possessing a polyethylene glycol unit of varying lengths. b, Calculated potential energy units (U) (kcal mol−1) of modelled compounds of varying methylene (CH2)n linker lengths for bivalent interactions with the catalytic site and the FKBP12 site. c, A convergent synthetic route for a bivalent mTOR inhibitor RapaLink-1.
